Introduction to Core Technologies
💧 Subcritical Water Extraction Technology (Patent No. 7141630)
The CP-101 series utilizes advanced subcritical water extraction technology. This method avoids the degradation of active ingredients and solvent residue issues commonly seen in traditional high-temperature or solvent-based extraction processes by using low-temperature subcritical water. It ensures the integrity and high bioactivity of the effective anticancer components found in Agaricus blazei.
🧬 Immune Checkpoint Inhibition Mechanism (CP-101 Mushroom Extract)
Acts on the PD-1 / PD-L1 pathway, releasing the suppression of T cells by tumors and restoring the immune system’s ability to recognize and attack cancer cells. Based on Nobel Prize-winning PD-1 immune mechanism research by Professor Tasuku Honjo in 2018.
🌿 Dendritic Cell Activation Pathway (CP-101 Mushroom Extract)
CP-101 activates key dendritic cells and macrophages within the immune system, enhancing the body's defense network.
GMP + ISO Dual Certification Assurance
All products are manufactured in GMP-certified factories in Japan and comply with ISO international quality standards. The entire production process is traceable, ensuring stability, safety, and compliance for every batch.
💊 Scientific Formulation × Patent-Activated Microcirculation Reconstruction (CP-101 Kokuhon Gokanmaru)
CP-101 Kokuhon Gokanmaru combines multiple natural active ingredients to precisely enhance vascular function. Its key component — Long Pepper extract (Japanese Patent No.: 6246859) — effectively activates the Tie2 signaling pathway, repairing capillary barriers and improving blood flow dynamics. By reconstructing microcirculatory networks, it supports efficient nutrient delivery and smooth energy distribution, offering core support for improving sub-health conditions such as fatigue, cold sensitivity, and swelling.
🛡️ Patented Ingredient Livinol™ (Patent No.: 5980228) (CP-101 Kangen Riki)
This product contains the patented ingredient Livinol™, which has been validated through multiple experiments to inhibit hepatitis, liver cancer, and fatty liver disease. Additionally, Livinol™ helps regulate gut microbiota and maintain balanced blood sugar levels. Its active compound, Garcinol, forms a strong protective barrier for liver health, supporting multi-level protection and repair.
Clinical Research Results
🔬 In Vivo Experiment: Immune Activation Verified in Lung Cancer Mouse Model (CP-101 Mushroom Extract)
In a mutated EGFR lung cancer mouse model, the experimental group (F2 group) fed with 2% CP-101 showed significantly reduced mRNA expression of three immune checkpoint-related genes — PD-L1, PD-L2, and CTLA4 — in lung tissues compared to the non-supplemented control group (NF group). Research findings: ✅ CP-101 effectively suppresses the expression of immune checkpoint molecules ✅ Confirms immunomodulatory and anti-tumor potential (Expression levels are represented as mRNA / GAPDH ratios; data represent average values obtained from tissue analysis after 6 weeks)
🧪 In Vitro Experiment: Suppression of Lung Cancer Cell Growth and Reduced Immune Checkpoint Expression (CP-101 Mushroom Extract)
In vitro studies showed that CP-101 applied to human lung cancer cell line A549 exhibited significant anti-cancer activity: ✅ Inhibited cancer cell proliferation within the concentration range of 10–200 μg/ml, showing dose-dependent effects ✅ Significantly reduced PD-L1 and PD-L2 mRNA expression within 24 hours at a concentration of 20 μg/ml Results confirm that CP-101 not only directly inhibits cancer cell growth but also modulates immune checkpoints to enhance immune recognition.
🌿 Immune Activation of Dendritic Cells by Agaricus Blazei Extract (CP-101 Mushroom Extract)
Studies show that Agaricus blazei extract can activate dendritic cells and enhance their immune-stimulating capabilities: ✅ Promotes expression of co-stimulatory molecules CD80 and CD86 ✅ Enhances secretion of IL-12 and IFN-γ, activating T-cell responses ✅ Exhibits dose-dependent activation, with higher extract concentrations leading to stronger effects By activating dendritic cells, Agaricus blazei indirectly exerts anti-tumor and immune-enhancing effects.
🔄 Triple Immune Synergy Mechanism (CP-101 Mushroom Extract)
The combination of CP-101, Shiitake mushroom, and Lactobacillus demonstrated significant immune-enhancing effects in experiments: ● Inhibits PD-L1 / PD-L2 / CTLA-4, activating immune cells ● Shiitake enhances anti-tumor immune response ● Lactobacillus regulates gut microbiome, supporting systemic immunity Experimental verification: When combined in a cellular model, the three components synergistically enhance immune recognition, attack, and stability
💫 Improved Peripheral Circulation (CP-101 Kokuhon Gokanmaru)
After administration of 120μg piperine, subjects showed a significant increase in skin temperature of hands, confirming improved peripheral circulation and relief of cold extremities.
📊 Significant Improvement in Lower Limb Edema Index (ECW/TBW) (CP-101 Kokuhon Gokanmaru)
In clinical trials, subjects taking CP-101 Kokuhon Gokanmaru showed a marked decrease in ECW/TBW (extracellular water ratio), indicating improved fluid distribution and reduced tissue edema.
🔬 Enhanced Tie2 Pathway Activation Stabilizes Vascular Structure (CP-101 Kokuhon Gokanmaru)
Experimental data show that following ingestion of CP-101 Kokuhon Gokanmaru, Tie2 pathway activity was enhanced in subjects. Activation of this pathway helps maintain endothelial cell stability, reducing fluid leakage due to increased vascular permeability, thereby stabilizing vascular structure and reducing tissue fluid loss.
👥 Subjective Feedback: Improved Mental State and Temperature Perception (CP-101 Kokuhon Gokanmaru)
Based on subjective feedback from users after taking CP-101 Kokuhon Gokanmaru, most reported improvements in mental state and reduced fatigue during continuous use. Some users also reported relief from cold hands and feet, an overall sense of warmth, increased energy, and improved performance in daily work and life activities.
📉 Significant Reduction in ALT and AST Liver Enzyme Levels (CP-101 KanGen Riki)
In animal experiments and early intervention models, continuous intake of "KanGen Riki" significantly reduced liver enzyme markers ALT and AST, indicating clear alleviation of liver cell damage and contributing to improved overall hepatic metabolic capacity.
🔍 Improvement in Fatty Liver Infiltration in Non-Alcoholic Fatty Liver Disease (NAFLD) (CP-101 KanGen Riki)
Research shows that taking "KanGen Riki" effectively reduces lipid deposition in liver cells and improves hepatic steatosis, providing a potential complementary improvement strategy for patients with non-alcoholic fatty liver disease (NAFLD).